Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQ0S4B)

Drug Name

NSC-66209 Drug Info

Synonyms

5407-46-5; Methyl fluorone black; 2,6,7-Trihydroxy-9-methylxanthen-3-one; NSC-66209; 2,6,7-Trihydroxy-9-methyl-xanthen-3-one; NSC 5426; UNII-KQC69H1NAG; KQC69H1NAG; 3H-Xanthen-3-one, 2,6,7-trihydroxy-9-methyl-; MLS000736515; MLS000123248; CHEMBL175266; 2,6,7-trihydroxy-9-methyl-3H-xanthen-3-one; NSC5426; NSC66209; 9-Methyl-2,3,7-trihydroxy-6-fluorone Hemisulfate; ST057760; SMR000123893; BAS 00532150; 9-METHYL-2,3,7-TRIHYDROXY-6-FLUORONE; EINECS 226-468-8; NSC 66209; AC1Q69RP; AC1L2IJ2; cid_72721; SCHEMBL2781454; CTK4J9473

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 72721
CAS Number: CAS 5407-46-5
TTD Drug ID: DMQ0S4B

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Candida Mannose-6-phosphate isomerase (Candi PMI1)	TT915ZD	MPI_CANAL	Inhibitor	[1]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	TTL53M6	MCL1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	DTT	MCL1	7.695	6.404	5.954	6.82

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	DTT	MCL1	1.06E-04	1.29	2.97

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.