Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQ6KZM)

Drug Name
ABI-009 Drug Info
Indication
Disease Entry ICD 11 Status REF
Malignant perivascular epithelioid cell tumour 2B5Y Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Non-muscle invasive bladder cancer 2C94 Phase 1/2 [1]
Pulmonary arterial hypertension BB01.0 Phase 1 [3]
Cross-matching ID
TTD Drug ID
DMQ6KZM

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Serine/threonine-protein kinase mTOR (mTOR) DTT MTOR 5.425 4.35 5.106 5.188
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Malignant perivascular epithelioid cell tumour
ICD Disease Classification 2B5Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serine/threonine-protein kinase mTOR (mTOR) DTT MTOR 2.16E-05 -0.44 -2.3
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT02494570) A Phase 2 Study of ABI-009 in Patients With Advanced Malignant PEComa.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)