Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQKDJZ)

Drug Name

DWJ-208 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Cancer related pain	MG30	Phase 1	[1]
Neuropathic pain	8E43.0	Phase 1	[1]
Pain	MG30-MG3Z	Investigative	[2]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)	TT4G2JS	SCN9A_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)	DTT	SCN9A	3.787	1.926	0.263	0.263

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Cancer related pain

ICD Disease Classification

MG30

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)	DTT	SCN9A	1.42E-03	-0.12	-0.36

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.