Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQS9OH)

Drug Name

N-(4-phenylsulfamoyl-naphthalen-1-yl)-benzamide Drug Info

Synonyms

CHEMBL222110; N-(4-phenylsulfamoyl-naphthalen-1-yl)-benzamide; SCHEMBL1337989

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 8 (CCR8)	TTE836A	CCR8_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-C chemokine receptor type 8 (CCR8)	DTT	CCR8	3.766	4.379	4.883	5.236

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-C chemokine receptor type 8 (CCR8)	DTT	CCR8	2.96E-02	0.07	0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem. 2007 Feb 8;50(3):566-84.