Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQSN7B)

• Drug Name: SR-31747 Drug Info
• Synonyms: SR-317417A

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 6439330
  CAS Number: CAS 132173-07-0
  TTD Drug ID: DMQSN7B

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholestenol delta-isomerase (EBP)	TT4VQZX	EBP_HUMAN	Modulator	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cholestenol delta-isomerase (EBP)	DTT	EBP	8.596	7.243	6.45	7.872

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 15 Disease of the musculoskeletal system/connective tissue
• Disease Class: ICD-11: FA20 Rheumatoid arthritis
• The Studied Tissue: Synovial tissue
• The Studied Disease: Rheumatoid arthritis [ICD-11:FA20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cholestenol delta-isomerase (EBP)	DTT	EBP	3.15E-03	0.25	0.89

References

• [1] Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302.