Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQXI9F)

Drug Name

L-Phenylalanine Drug Info

Synonyms

Endophenyl; Fenilalanina; Phe; Phenylalanine; Phenylalaninum; Fenilalanina [Spanish]; Phenylalaninum [Latin]; Antibiotic FN 1636; CB 3208; NCI9959; Alpha-Aminohydrocinnamic acid; Beta-Phenylalanine; L-Antibiotic FN 1636; L-PHENYLALININE; N-Formylmelphalan; Phenylalanine (VAN); H-Phe-OH; L-Phenylalanine (JP15); Phenylalanine (USP/INN); Phenylalanine [USAN:INN:JAN]; Beta-Phenyl-L-alanine; N-Formyl-L-sarcolysin; N-Formyl-L-p-sarcolysin; L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine; L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-(9CI); (2S)-2-amino-3-phenylpropanoic acid; (L)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-2-Amino-3-phenylpropanoic acid; (S)-2-Amino-3-phenylpropionic acid; (S)-Phenylalanine; (S)-alpha-Amino-benzenepropanoic acid; (S)-alpha-Amino-beta-phenylpropionic acid; (S)-alpha-Aminohydrocinnamic acid; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; 3-Phenyl-L-alanine; 3-Phenylalanine; 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-formamidopropanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Malnutrition	5B50-5B71	Approved	[1] , [2]

Therapeutic Class

Dietary supplement

Cross-matching ID

PubChem CID: 6140
ChEBI ID: CHEBI:17295
CAS Number: CAS 63-91-2
TTD Drug ID: DMQXI9F
VARIDT Drug ID: DR00266
INTEDE Drug ID: DR2108

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine 3-monooxygenase (TH)	TTUHP71	TY3H_HUMAN	Binder	[3] , [4] , [5]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
L-type amino acid transporter 3 (SLC43A1)	DTBMSWG	LAT3_HUMAN	Approved	[6]
L-type amino acid transporter 4 (SLC43A2)	DTK02I1	LAT4_HUMAN	Approved	[7]
L-type amino acid transporter 2 (SLC7A8)	DTJF3DX	LAT2_HUMAN	Approved	[8]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Phenylalanine--tRNA ligase mitochondrial (FARS2)	DE0WGR8	SYFM_HUMAN	Phase 4	[9]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosine 3-monooxygenase (TH)	DTT	TH	2.322	2.233	2.036	2.07
L-type amino acid transporter 2 (SLC7A8)	DTP	LAT2	5.741	6.763	7.117	6.583
L-type amino acid transporter 3 (SLC43A1)	DTP	LAT3	7.459	6.408	6.24	6.562
Phenylalanine--tRNA ligase mitochondrial (FARS2)	DME	FARS2	5.928	5.641	6.033	5.89

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Malnutrition

ICD Disease Classification

5B50-5B71

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosine 3-monooxygenase (TH)	DTT	TH	9.10E-04	-2.73	-1.55
L-type amino acid transporter 4 (SLC43A2)	DTP	LAT4	5.91E-01	-1.43E-01	-4.28E-01
L-type amino acid transporter 2 (SLC7A8)	DTP	LAT2	7.23E-02	-2.92E-01	-4.31E-01
L-type amino acid transporter 3 (SLC43A1)	DTP	LAT3	9.31E-01	-1.82E-01	-8.57E-01
Phenylalanine--tRNA ligase mitochondrial (FARS2)	DME	FARS2	1.42E-01	-4.02E-01	-8.90E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3313).
2	Drug information of L-Alanine, Health Canada, 2008. (drugid: 1025)
3	Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
4	Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
5	In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes. Biochem Biophys Res Commun. 2003 Feb 7;301(2):610-6.
6	Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45.
7	Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542.
8	Quantifying the relative contributions of different solute carriers to aggregate substrate transport. Sci Rep. 2017 Jan 16;7:40628.
9	Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. J Mol Biol. 1999 May 14;288(4):567-77.