Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMR2B4O)

• Drug Name: Phenyl-(5-phenyl-oxazol-2-yl)-amine Drug Info
• Synonyms: N,5-diphenyl-1,3-oxazol-2-amine; 2-Oxazolamine, N,5-diphenyl-; 135307-33-4; GW549390X; aminoxazole 24; ACMC-20mvpu; AC1NS6QQ; 2-Anilino-5-aryloxazole 5; CHEMBL318728; BDBM5364; SCHEMBL3295009; CTK0B9820; DTXSID80416185; HMS3303G19; HMS3305C03; ZINC13611247; NCGC00242146-01; DA-45813; FT-0704302

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5329404
  CAS Number: CAS 135307-33-4
  TTD Drug ID: DMR2B4O

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]
Vascular endothelial growth factor receptor 3 (FLT-4)	TTDCBX5	VGFR3_HUMAN	Inhibitor	[1]
VEGFR1 messenger RNA (VEGFR1 mRNA)	TT1VAUK	VGFR1_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Vascular endothelial growth factor receptor 3 (FLT-4)	DTT	FLT4	3.053	3.655	3.766	4.986
VEGFR1 messenger RNA (VEGFR1 mRNA)	DTT	FLT1	4.802	4.95	4.597	3.17

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor receptor 2 (KDR)	DTT	KDR	1.98E-01	0.11	0.2
Vascular endothelial growth factor receptor 3 (FLT-4)	DTT	FLT4	6.00E-01	-0.04	-0.23
VEGFR1 messenger RNA (VEGFR1 mRNA)	DTT	FLT1	1.64E-05	0.29	0.51

References

• [1] Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9.