Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMS4JAG)

Drug Name

(S)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline Drug Info

Synonyms

(3S)-3-methyl-1,2,3,4-tetrahydroisoquinoline; CHEMBL294079; (s)-3-methyl-1,2,3,4-tetrahydroisoquinoline; 15547-43-0; J-501273; AC1OM1IZ; (S)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline; SCHEMBL1690518; ZINC19928408; FCH855835; BDBM50052884; AKOS006286080; AB39365; AJ-75701; KB-31985; (3S)-1,2,3,4-tetrahydro-3-methyl-isoquinoline; Isoquinoline, 1,2,3,4-tetrahydro-3-methyl-, (3S)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 7462302
TTD Drug ID: DMS4JAG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.