Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMS9EKG)

• Drug Name: VCL-1M01 Drug Info
• Synonyms: VCL-IM01; EPT (plasmid DNA), Vical; IL-2/EP; MedPulser, cancer (plasmid DNA), Vical; Plasmid DNA (transdermal, EPT), Vical; IL-2 gene therapy (plasmid, transdermal, melanoma); IL-2 gene therapy (pVCL-1102 plasmid DNA vector, melanoma), Vical; IL-2 gene therapy (plasmid, transdermal, melanoma), Vical

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMS9EKG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-2 (IL2)	TTF89GD	IL2_HUMAN	Modulator	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Interleukin-2 (IL2)	DTT	IL2	0.848	4.548	3.548	4.053

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Melanoma
• ICD Disease Classification: 2C30

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin-2 (IL2)	DTT	IL2	7.64E-01	1.04E-02	0.07

References

• [1] ClinicalTrials.gov (NCT00223899) A Trial to Evaluate the Safety of Intratumoral VCL-IM01 Followed by Electroporation in Metastatic Melanoma. U.S. National Institutes of Health.
• [2] Interleukin-2 gene therapy in a patient with glioblastoma. Gene Ther. 1995 Mar;2(2):164-7.