Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSAFUK)

Drug Name

2-amino-2-(2,4-difluorophenyl)acetic acid Drug Info

Synonyms

2-amino-2-(2,4-difluorophenyl)acetic Acid; 240409-02-3; 2,4-DIFLUORO-DL-PHENYLGLYCINE; amino(2,4-difluorophenyl)acetic acid; CHEMBL382622; Amino-(2,4-difluoro-phenyl)-acetic acid; alpha-Amino-2,4-difluorobenzeneacetic acid; AC1MC6PH; SCHEMBL1115280; CTK7I4174; DTXSID70371799; MolPort-000-165-848; COIWYFIMAXMSKX-UHFFFAOYSA-N; AC1Q5058; KS-00003QV7; BDBM50179695; SBB090539; AKOS016051288; AKOS000170674; PS-6697; QC-3701; AB11996; RP03495; SC-59456; FT-0691426; BB 0249675; 2-aMino-2-(2;4-difluorophenyl)acetic acid; Y8397; EN300-88022

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2737050
CAS Number: CAS 240409-02-3
TTD Drug ID: DMSAFUK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	5.083	4.833	5.343	2.536

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	9.36E-01	-0.03	-0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	2.81E-05	-0.15	-0.68

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.