General Information of Drug (ID: DMSI0HE)

Drug Name
TZI-41127 Drug Info
Synonyms
Tzi-41127; 104007-80-9; 2-(4-Hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole; CHEMBL76586; Phenol,4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethyl-; OZFHUMGEWVYBRM-UHFFFAOYSA-N; ACMC-1BUG2; AC1L2TV9; SCHEMBL10459430; CTK4A2589; DTXSID20146217; Phenol, 4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethyl-; BDBM50283452; 4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethylphenol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
128480
CAS Number
CAS 104007-80-9
TTD Drug ID
DMSI0HE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.966 5.133 5.358 6.128
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.15E-01 -0.06 -0.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic properties, Bioorg. Med. Chem. Lett. 4(20):2383-2388 (1994).