Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSI0HE)

Drug Name

TZI-41127 Drug Info

Synonyms

Tzi-41127; 104007-80-9; 2-(4-Hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole; CHEMBL76586; Phenol,4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethyl-; OZFHUMGEWVYBRM-UHFFFAOYSA-N; ACMC-1BUG2; AC1L2TV9; SCHEMBL10459430; CTK4A2589; DTXSID20146217; Phenol, 4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethyl-; BDBM50283452; 4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethylphenol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 128480
CAS Number: CAS 104007-80-9
TTD Drug ID: DMSI0HE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic properties, Bioorg. Med. Chem. Lett. 4(20):2383-2388 (1994).