Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSQRXW)

Drug Name
SQ-32709 Drug Info
Synonyms
farnesyl diphosphate; farnesyl pyrophosphate; (2E,6E)-Farnesyl diphosphate; trans,trans-Farnesyl diphosphate; all-trans-Farnesyl pyrophosphate; (all-E)-Farnesyl diphosphate; (E,E)-Farnesyl pyrophosphate; (2E,6E)-Farnesyl pyrophosphate; trans-Farnesyl pyrophosphate; 2-trans,6-trans-Farnesyl pyrophosphate; farnesyl-PP; (E,E)-Farnesyl diphosphate; 2-trans,6-trans-farnesyl diphosphate; trans-trans-farnesyl diphosphate; UNII-79W6B01D07; CHEBI:17407; trans,trans-Farnesyl pyrophosphate; Sq 32709; 13058-04-3; CHEMBL69330
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
445713
ChEBI ID
CHEBI:17407
CAS Number
CAS 372-97-4
TTD Drug ID
DMSQRXW
INTEDE Drug ID
DR1927

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Squalene synthetase (FDFT1) TTFQEO5 FDFT_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Ras proteins prenyltransferase alpha (FNTA) DEFNVD7 FNTA_HUMAN Discontinued [3]
Squalene synthase (FDFT1) DEIDTHQ FDFT_HUMAN Discontinued [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Squalene synthetase (FDFT1) DTT FDFT1 7.652 8.602 8.32 8.907
Squalene synthase (FDFT1) DME FDFT1 7.652 8.602 8.32 8.907
Ras proteins prenyltransferase alpha (FNTA) DME FNTA 7.914 8.13 7.856 8.107
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Arteriosclerosis
ICD Disease Classification BD40
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Squalene synthetase (FDFT1) DTT FDFT1 7.85E-01 -0.09 -0.38
Squalene synthase (FDFT1) DME FDFT1 7.85E-01 -9.18E-02 -3.76E-01
Ras proteins prenyltransferase alpha (FNTA) DME FNTA 6.96E-05 6.61E-01 1.40E+00
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005302)
2 Clinical pharmacokinetics and pharmacodynamics of a new squalene synthase inhibitor, BMS-188494, in healthy volunteers. J Clin Pharmacol. 1998 Dec;38(12):1116-21.
3 Site-selective enzymatic labeling of designed ankyrin repeat proteins using protein farnesyltransferase. Methods Mol Biol. 2019;2033:207-219.
4 Increased activity of the sterol branch of the mevalonate pathway elevates glycosylation of secretory proteins and improves antifungal properties of Trichoderma atroviride. Fungal Genet Biol. 2020 Jan 17;137:103334.