General Information of Drug (ID: DMSTL12)

Drug Name
RG7232 Drug Info
Indication
Disease Entry ICD 11 Status REF
Dyslipidemia 5C80-5C81 Investigative [1]
Cross-matching ID
TTD Drug ID
DMSTL12

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ATP-binding cassette transporter A1 (ABCA1) TTJW1GN ABCA1_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ATP-binding cassette transporter A1 (ABCA1) DTT ABCA1 6.113 4.838 4.44 3.104
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Dyslipidemia
ICD Disease Classification 5C80-5C81
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ATP-binding cassette transporter A1 (ABCA1) DTT ABCA1 4.88E-01 -0.1 -0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Analysis of "On/Off" Kinetics of a CETP Inhibitor Using a Mechanistic Model of Lipoprotein Metabolism and Kinetics. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):465-73.