Details of the Drug

General Information of Drug (ID: DMSTL12)

Drug Name

RG7232

Indication

Disease Entry	ICD 11	Status	REF
Dyslipidemia	5C80-5C81	Investigative	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ATP-binding cassette transporter A1 (ABCA1)	TTJW1GN	ABCA1_HUMAN	Modulator	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Dyslipidemia

ICD Disease Classification

5C80-5C81

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ATP-binding cassette transporter A1 (ABCA1)	DTT	ABCA1	4.88E-01	-0.1	-0.33

Molecular Expression Atlas (MEA)

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References

1	Analysis of "On/Off" Kinetics of a CETP Inhibitor Using a Mechanistic Model of Lipoprotein Metabolism and Kinetics. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):465-73.