Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSVWI7)

Drug Name

Neladenoson bialanate Drug Info

Synonyms

UNII-IV690462VZ; IV690462VZ; 1239309-58-0; Neladenoson dalanate; Neladenoson dalanate [INN]; Neladenoson bialanate [INN]; SCHEMBL7904070; AKOS032946515; DB13138; L-Alanine, L-alanyl-, 2-(4-(2-(((2-(4-chlorophenyl)-4-thiazolyl)methyl)thio)-3,5-dicyano-6-(1-pyrrolidinyl)-4-pyridinyl)phenoxy)ethyl ester; 2-(4-(2-(((2-(4-Chlorophenyl)-1,3-thiazol-4-yl)methyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl L-alanyl-L-alaninate

Indication

Disease Entry	ICD 11	Status	REF
Chronic heart failure	BD1Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 56848985
CAS Number: CAS 1239309-58-0
TTD Drug ID: DMSVWI7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ADORA1 messenger RNA (ADORA1 mRNA)	TT92EIB	AA1R_HUMAN	Agonist	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
ADORA1 messenger RNA (ADORA1 mRNA)	DTT	ADORA1	4.698	5.291	5.298	4.797

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Chronic heart failure

ICD Disease Classification

BD1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ADORA1 messenger RNA (ADORA1 mRNA)	DTT	ADORA1	1.74E-01	-0.13	-0.36

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)