Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT0DW4)

• Drug Name: Rotigitine Drug Info
• Synonyms: Rotigotine hydrochloride; 125572-93-2; Rotigotine HCl; Rotigotine (Hydrochloride); UNII-6Q1W9573L2; (S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride; 6Q1W9573L2; (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride; [14C]-Rotigotine; N-0923 hydrochloride; N 0924 hydrochloride; Rotigotine(Hydrochloride); Neupro Hydrochloride Salt; C19H26ClNOS; AC1L46ZH; (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochlor

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 180335
  CAS Number: CAS 125572-93-2
  TTD Drug ID: DMT0DW4

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine D2 receptor (D2R)	DTT	DRD2	5.345	5.634	5.789	5.901

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Parkinson disease
• ICD Disease Classification: 8A00.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	2.50E-02	-0.08	-0.49

References

• [1] Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54.