General Information of Drug (ID: DMT4RI2)

Drug Name
Isoquinoline-1,3,4(2H)-trione Drug Info
Synonyms
Phthalonimide; 1,3,4(2H)-Isoquinolinetrione; isoquinoline-1,3,4(2H)-trione; 521-73-3; isoquinoline-1,3,4-trione; 1,3,4-(2H)ISOQUINOLINETRIONE; UNII-BM68CV5X6Q; NSC 407248; BRN 0383773; BM68CV5X6Q; 1,2,3,4-tetrahydroisoquinoline-1,3,4-trione; isoquinoline-1,3,4-(2H)-trione; 3deh; NSC407248; AC1L1VMV; 5-21-11-00575 (Beilstein Handbook Reference); 1,4(2H)-Isoquinolinetrione; SCHEMBL1122624; Isoquinoline-1,3,4-trione 1; CHEMBL206435; CTK1H0848; BDBM10247; DTXSID40200103; ZINC1599708; FCH844329; ACM521733; AKOS006276226; NSC-407248
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10640
CAS Number
CAS 521-73-3
TTD Drug ID
DMT4RI2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Caspase (CASP) TTZY5KP NOUNIPROTAC Inhibitor [1]
Caspase 6 messenger RNA (CASP6 mRNA) TTKW4ML CASP6_HUMAN Inhibitor [1]
Caspase 8 messenger RNA (CASP8 mRNA) TT6SZNG CASP8_HUMAN Inhibitor [1]
Caspase-3 (CASP3) TTPF2QI CASP3_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Caspase-3 (CASP3) DTT CASP3 6.469 6.744 6.142 7.184
Caspase 8 messenger RNA (CASP8 mRNA) DTT CASP8 5.477 5.033 5.668 5.261
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Caspase-3 (CASP3) DTT CASP3 3.36E-01 0.03 0.05
Caspase 8 messenger RNA (CASP8 mRNA) DTT CASP8 8.78E-06 1.43 4.51
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.