Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT9FJZ)

Drug Name

AGROCLAVINE Drug Info

Synonyms

Agroclavine; 8,9-Didehydro-6,8-dimethylergoline; 548-42-5; UNII-A8SW57GO7T; (-)-agroclavine; CCRIS 2099; Ergoline, 8,9-didehydro-6,8-dimethyl-; EINECS 208-947-3; (5R,10R)-agroclavine; NSC 93132; 6,8-Dimethyl-8,9-didehydroergoline; AGROCLAVIN; BRN 0024966; A8SW57GO7T; CHEMBL449081; CHEBI:2519; Indolo(4,3-fg)quinoline, 4,6,6a,7,8,10a-hexahydro-7,9-dimethyl-; NSC93132; (6aR,10aR)-7,9-dimethyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinoline; agroclavine-1; Lopac-A-206; AC1L2JXJ; Biomol-NT_000066; Lopac0_000128; MLS001216424; cid_73484

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 73484
ChEBI ID: CHEBI:2519
CAS Number: CAS 548-42-5
TTD Drug ID: DMT9FJZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
5-HT 1D receptor (HTR1D)	DTT	HTR1D	3.307	1.263	2.585	5.833

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Ergolines as selective 5-HT1 agonists. J Med Chem. 1988 Aug;31(8):1512-9.