Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTJ1NH)

Drug Name

L-serine-O-phosphate Drug Info

Synonyms

Phosphoserine; O-phospho-L-serine; Dexfosfoserine; phosphoserine; 407-41-0; L-O-Phosphoserine; Fosforina; O-Phosphoserine; L-SOP; L-Phosphoserine; PHOSPHONOSERINE; 3-phosphoserine; L-Serine O-phosphate; Dexfosfoserine [INN]; Phosphatidalserine; 3-O-Phosphoserine; H-Ser(PO3H2)-OH; O-phosphono-L-serine; serine, O-phosphono-; (+)-L-Serine dihydrogen phosphate (ester); L-Seryl phosphate; UNII-VI4F0K069V; L-3-Phosphoserine; L-O-Serine phosphate; L-Serinephosphoric acid; H-Ser(PO)-OH; L-2-amino-3-hydroxypropanoic acid 3-phosphate; LSOP; Phosphonoserine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

Cross-matching ID

PubChem CID: 68841
ChEBI ID: CHEBI:15811
CAS Number: CAS 407-41-0
TTD Drug ID: DMTJ1NH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]
Metabotropic glutamate receptor 4 (mGluR4)	TTICZ1O	GRM4_HUMAN	Agonist	[3]
Metabotropic glutamate receptor 6 (mGluR6)	TTWRP2F	GRM6_HUMAN	Agonist	[4]
Metabotropic glutamate receptor 7 (mGluR7)	TT0I76D	GRM7_HUMAN	Agonist	[5]
Metabotropic glutamate receptor 8 (mGluR8)	TT0IFKL	GRM8_HUMAN	Agonist	[6]
Phosphoinositide dependent protein kinase-1 (PDPK1)	TT9QBI6	PDPK1_HUMAN	Inhibitor	[1]
Protein kinase C theta (PRKCQ)	TT8QL1J	KPCT_HUMAN	Inhibitor	[1]
Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC)	TTLP3GX	ALGC_PSEAE	Inhibitor	[1]
Rhodopsin (RHO)	TTH0KSX	OPSD_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glycogen phosphorylase muscle form (GP)	DTT	PYGM	4.036	5.34	6.256	6.062
Protein kinase C theta (PRKCQ)	DTT	PRKCQ	6.31	6.97	6.97	6.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glycogen phosphorylase muscle form (GP)	DTT	PYGM	2.69E-01	-0.23	-0.14

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1411).
3	Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 1993 Sep;4(9):1099-101.
4	Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacology. 1997 Feb;36(2):145-52.
5	Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
6	Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10.