Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTOA1Q)

Drug Name
PMID29334795-Compound-21 Drug Info
Indication
Disease Entry ICD 11 Status REF
Corticobasal degeneration 8A00.1Y Patented [1]
Progressive supranuclear palsy 8A00.10 Patented [1]
Cross-matching ID
TTD Drug ID
DMTOA1Q

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H3 receptor (H3R) TT9JNIC HRH3_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histamine H3 receptor (H3R) DTT HRH3 3.225 3.399 3.17 3.027
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Corticobasal degeneration
ICD Disease Classification 8A00.1Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H3 receptor (H3R) DTT HRH3 3.62E-02 -0.09 -0.22
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196.