Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTS4YD)

Drug Name

3-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridine Drug Info

Synonyms

CHEMBL462092; 1092522-84-3; 3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)pyridine; 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridine; 3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pyridine; ZINC40873967; BDBM50273702

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 25180306
TTD Drug ID: DMTS4YD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87.