Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTUL9J)

Drug Name

Adamantan-1-yl-piperidin-1-yl-methanone Drug Info

Synonyms

Adamantan-1-yl-piperidin-1-yl-methanone; adamantanyl piperidyl ketone; CHEMBL245590; 1-adamantyl(piperidino)methanone; 22508-49-2; (3r,5r,7r)-adamantan-1-yl(piperidin-1-yl)methanone; 1-adamantyl(piperidin-1-yl)methanone; SMR000117086; AC1LBKY9; Maybridge1_008125; Oprea1_633750; Oprea1_290126; MLS000526612; Piperidino(1-adamantyl) ketone; SCHEMBL3457055; SCHEMBL19841773; CTK7F5375; HMS564J07; BURUIZXRHQWZQI-UHFFFAOYSA-N; MolPort-001-930-823; 1-(1-Adamantylcarbonyl)piperidine; HMS2178P18; ZINC4031797

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 584509
TTD Drug ID: DMTUL9J

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	10.967	5.178	5.865	6.377

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43.