General Information of Drug (ID: DMTUR6C)

Drug Name
Rac-2-amino-4-phenylbutanoic acid Drug Info
Synonyms
DL-Homophenylalanine; 1012-05-1; 2-Amino-4-phenylbutanoic acid; h-dl-hophe-oh; 2-Amino-4-phenylbutyric acid; (-)-2-Amino-4-phenylbutyric acid; H-DL-HOMOPHE-OH; H-DL-HPH-OH; 2-amino-4-phenyl-butyric acid; 7636-28-4; CHEMBL203873; Benzylalanine; JTTHKOPSMAVJFE-UHFFFAOYSA-N; Benzenebutanoic acid, alpha-amino-; (RS)-2-AMINO-4-PHENYL-BUTYRIC ACID; dlhpa; MFCD00063091; rac-2-amino-4-phenylbutanoic acid; d,l-homophenylalanine; ACMC-209tws; AC1L2SZU; DL-Homophenylalanine, 98%; KSC492S1B; SCHEMBL130567; AC1Q5S74; AC1Q50B0; KS-00000FXF
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
102530
CAS Number
CAS 1012-05-1
TTD Drug ID
DMTUR6C

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.