Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTW2XB)

Drug Name

LY3556050 Drug Info

Synonyms

SCHEMBL16252692; BDBM311911; US10166214, Example 47; AT36106; LY3556050; EN300-1700347; Z3071648657; (1R,5S,6R)-N-{2-methyl-1-[(3-methylpyridin-2-yl)oxy]propan-2-yl}-3-azabicyclo[3.1.0]hexane-6-carboxamide; 1638588-92-7

Indication

Disease Entry	ICD 11	Status	REF
Chronic low-back pain	MG30	Phase 2	[1]

Cross-matching ID

PubChem CID: 86294067
TTD Drug ID: DMTW2XB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Somatostatin receptor type 4 (SSTR4)	TTAE1BR	SSR4_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Somatostatin receptor type 4 (SSTR4)	DTT	SSTR4	5.615	5.998	3.7	6.158

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Chronic low-back pain

ICD Disease Classification

MG30

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Somatostatin receptor type 4 (SSTR4)	DTT	SSTR4	1.12E-02	-0.07	-0.32

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT04874636) Randomized, Placebo-Controlled, Phase 2 Clinical Trial to Evaluate LY3556050 for the Treatment of Chronic Low Back Pain. U.S.National Institutes of Health.