General Information of Drug (ID: DMTW2XB)

Drug Name
LY3556050
Synonyms
SCHEMBL16252692; BDBM311911; US10166214, Example 47; AT36106; LY3556050; EN300-1700347; Z3071648657; (1R,5S,6R)-N-{2-methyl-1-[(3-methylpyridin-2-yl)oxy]propan-2-yl}-3-azabicyclo[3.1.0]hexane-6-carboxamide; 1638588-92-7
Indication
Disease Entry ICD 11 Status REF
Chronic low-back pain MG30 Phase 2 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C16H23N3O2
Canonical SMILES
CC1=C(N=CC=C1)OCC(C)(C)NC(=O)C2C3C2CNC3
InChI
InChI=1S/C16H23N3O2/c1-10-5-4-6-18-15(10)21-9-16(2,3)19-14(20)13-11-7-17-8-12(11)13/h4-6,11-13,17H,7-9H2,1-3H3,(H,19,20)/t11-,12+,13?
InChIKey
PCINBSQTEDBZDB-FUNVUKJBSA-N
Cross-matching ID
PubChem CID
86294067
TTD ID
DXE53Z

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatostatin receptor type 4 (SSTR4) TTAE1BR SSR4_HUMAN Agonist [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Chronic low-back pain
ICD Disease Classification MG30
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Somatostatin receptor type 4 (SSTR4) DTT SSTR4 1.12E-02 -0.07 -0.32
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04874636) Randomized, Placebo-Controlled, Phase 2 Clinical Trial to Evaluate LY3556050 for the Treatment of Chronic Low Back Pain. U.S.National Institutes of Health.