Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTZQUJ)

Drug Name
PMID18068976C25 Drug Info
Synonyms GTPL8568; BDBM50229655
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44447430
TTD Drug ID
DMTZQUJ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ADAM10 messenger RNA (ADAM10 mRNA) TTVXEGU ADA10_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ADAM10 messenger RNA (ADAM10 mRNA) DTT ADAM10 5.86 6.053 6.109 5.874
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ADAM10 messenger RNA (ADAM10 mRNA) DTT ADAM10 9.12E-20 0.59 0.82
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett. 2008 Jan 15;18(2):560-4.