Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMU5NRA)

Drug Name

3,4,5-trimethoxy-N-(thiazol-2-yl)benzamide Drug Info

Synonyms

3,4,5-Trimethoxy-N-(1,3-thiazol-2-yl)benzamide; 50591-71-4; AC1LCU6P; Cambridge id 5149479; Oprea1_821264; MLS000027375; CHEMBL225354; ZINC45264; XSAYHNGEJLPKEX-UHFFFAOYSA-N; MolPort-000-653-421; HMS2331F23; STK731712; AKOS001625155; MCULE-9743171840; NCGC00018998-01; NCGC00018998-02; ST067007; SMR000034190; Benzamide, 3,4,5-trimethoxy-N-2-thiazolyl-; Thiazole, 2-(3,4,5-trimethoxybenzoylamino)-; 3,4,5-trimethoxy-N-1,3-thiazol-2-ylbenzamide; SR-01000000944; SR-01000000944-2; Z28173733

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 606801
TTD Drug ID: DMU5NRA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
LOX-5 messenger RNA (ALOX5 mRNA)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
LOX-5 messenger RNA (ALOX5 mRNA)	DTT	ALOX5	9.43E-03	0.14	0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6.