Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMU8KOD)

Drug Name
Anakinra Drug Info
Synonyms Kineret; Kineret (TN); Anakinra (USAN/INN)
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [2]
CINCA syndrome Investigative [3]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
TTD Drug ID
DMU8KOD

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 1 receptor type 1 (IL1R1) TTWOTEA IL1R1_HUMAN Antagonist [4]
HUMAN interleukin-1 receptor 1 (IL1R1) TTT7FOP IL1R1_HUMAN Antagonist [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interleukin 1 receptor type 1 (IL1R1) DTT IL1R1 8.25 7.361 8.074 6.812
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Rheumatoid arthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin 1 receptor type 1 (IL1R1) DTT IL1R1 2.02E-03 0.65 1.01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (BLA) 103950.
2 ClinicalTrials.gov (NCT04364009) Anakinra for COVID-19 Respiratory Symptoms. U.S. National Institutes of Health.
3 Clinical and genetic characterization of Italian patients affected by CINCA syndrome. Rheumatology (Oxford). 2007 Mar;46(3):473-8.
4 IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes. Eur Cytokine Netw. 2009 Jun 1;20(2):81-87.
5 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (BLA) 125166.