Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUA0XC)

Drug Name
ALF-5755 Drug Info
Synonyms HIP/PAP; Hepatocarcinoma-intestine-pancreas/pancreatic-associated protein
Indication
Disease Entry ICD 11 Status REF
Liver failure DB99.7 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMUA0XC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Regenerating human pro-islet peptide (REG3A) TTL4H8N REG3A_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Regenerating human pro-islet peptide (REG3A) DTT REG3A 5.755 5.675 5.217 12.045
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 13 Disease of the digestive system
Disease Class ICD-11: DD91 Irritable bowel syndrome
The Studied Tissue Liver tissue
The Studied Disease Liver failure [ICD-11:DD91.0]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Regenerating human pro-islet peptide (REG3A) DTT REG3A 1.68E-02 -0.13 -0.87
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01318525) Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure. U.S. National Institutes of Health.
2 HIP/PAP prevents excitotoxic neuronal death and promotes plasticity. Ann Clin Transl Neurol. 2014 October; 1(10): 739-754.