Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUB3OY)

Drug Name
RO-5323441 Drug Info
Synonyms Placental growth factor inhibitors (humanized mAb, cancer), BioInvent/Thrombogenics/Roche; 89Zr-RO-5323441
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMUB3OY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Placenta growth factor (PlGF) TT48I1Y PLGF_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Placenta growth factor (PlGF) DTT PGF 6.163 7.095 7.039 7.016
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Placenta growth factor (PlGF) DTT PGF 1.44E-03 -0.32 -1.84
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01622764) 89Zr-RO5323441 PET Imaging in Glioblastoma. U.S. National Institutes of Health.
2 RO5323441, a humanized monoclonal antibody against the placenta growth factor, blocks PlGF-induced VEGFR-1 phosphorylation in vitro and tumor growth in vivo. Cancer Research. 01/2011.