Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUD6IK)

Drug Name

BXL-746 Drug Info

Synonyms

VD3 analogs (inflammation), BioXell; VD3 analogs (inflammation), Roche; Vitamin D3 analogs (inflammation), BioXell; Vitamin D3 analogs (inflammation), Roche; Deuterated Gemini, (inflammation), BioXell

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Discontinued in Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMUD6IK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vitamin D3 receptor (VDR)	TTK59TV	VDR_HUMAN	Stimulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Vitamin D3 receptor (VDR)	DTT	VDR	4.536	6.7	5.109	7.303

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Inflammation

ICD Disease Classification

1A00-CA43.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vitamin D3 receptor (VDR)	DTT	VDR	1.69E-02	-0.23	-0.66

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025073)
2	Inter-species differences in sensitivity to the calcemic activity of the novel 1,25-dihydroxyvitamin D3 analog BXL746. Regul Toxicol Pharmacol. 2008 Dec;52(3):332-41.