Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUNFEP)

Drug Name
GDC0310 Drug Info
Synonyms RG6029; FCTMRPTVPHVTTN-UHFFFAOYSA-N; SCHEMBL16770884; BDBM71258; BCP25347; US9694002, 346; 1788066-71-6
Indication
Disease Entry ICD 11 Status REF
Chronic pain MG30 Phase 1 [1]
Cross-matching ID
PubChem CID
118120526
TTD Drug ID
DMUNFEP
VARIDT Drug ID
DR01055

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.7 (SCN9A) TT4G2JS SCN9A_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DTT SCN9A 3.787 1.926 0.263 0.263
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Chronic pain
ICD Disease Classification MG30
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DTT SCN9A 1.42E-03 -0.12 -0.36
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)