Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUQ6P4)

Drug Name

N-(1-benzylpiperidine-4-yl)-2-naphthamide Drug Info

Synonyms

CHEMBL228972; N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide; N-(1-benzylpiperidine-4-yl)-2-naphthamide; MolPort-005-630-484; BDBM50203383; ZINC12985947; STK491618; AKOS003382305; MCULE-1935524858; N-(1-benzylpiperidin-4-yl)-2-naphthamide; ST50877721; 2-naphthyl-N-[1-benzyl(4-piperidyl)]carboxamide; Z32353863

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16725912
TTD Drug ID: DMUQ6P4

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the a... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4.