Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMV0C6F)

Drug Name

1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine Drug Info

Synonyms

1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine; CHEMBL293399; 80888-36-4; Psi-DOM; SCHEMBL2562975; DTXSID20548454; 2,6-dimethoxy-4-methylamphetamine; BDBM50115832; 2,6-Dimethoxy-alpha,4-dimethylbenzeneethanamine; Benzeneethanamine, 2,6-dimethoxy-alpha,4-dimethyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 13753734
CAS Number: CAS 80888-36-4
TTD Drug ID: DMV0C6F

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9.