Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVD05E)

Drug Name

(S)-2-amino-2-cyclohexylacetic acid Drug Info

Synonyms

14328-51-9; h-chg-oh; l-alpha-cyclohexylglycine; L-Cyclohexylglycine; (S)-2-amino-2-cyclohexylacetic acid; h-cyclohexyl-gly-oh; L-(+)-2-Cyclohexylglycine; (2s)-amino(cyclohexyl)acetic acid; CYCLOHEXYLGLYCYL; 2-Cyclohexyl-L-glycine; (2S)-2-amino-2-cyclohexylacetic acid; CYCLOHEXYL-GLYCINE; l-cyclohexyl glycine; (s)-cyclohexylglycine; L-2-Cyclohexylglycine; h-cyclohexyl-d-gly-oh; CHEMBL382372; UNII-59Q5O5615E; (S)-Amino-cyclohexyl-acetic acid; (2S)-amino(cyclohexyl)ethanoic acid; MFCD01311679; 59Q5O5615E; l-(-)-cyclohexylglycine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 736848
CAS Number: CAS 14328-51-9
TTD Drug ID: DMVD05E

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	5.083	4.833	5.343	2.536

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	9.36E-01	-0.03	-0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	2.81E-05	-0.15	-0.68

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.