Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVG3K1)

Drug Name

APA Drug Info

Synonyms

1-Aminooxy-3-aminopropane; 3-aminooxy-1-aminopropane; O-(3-aminopropyl)hydroxylamine; 98532-00-4; CHEMBL281021; 1-Propanamine, 3-(aminooxy)-; 3-Aminooxy-1-propanamine; XAP; 3-Aminooxypropylamine; 3-(aminooxy)propan-1-amine; GTPL5139; AC1L22F5; CTK3I7322; DTXSID20243634; BDBM50005719; AKOS006348478; (APA)O-(3-Amino-propyl)-hydroxylamine; O-(3-Aminopropyl)hydroxylamine,; 1-aminooxy-3-aminopropane

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 65020
CAS Number: CAS 98532-00-4
TTD Drug ID: DMVG3K1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Ornithine decarboxylase (ODC1)	DTT	ODC1	9.956	8.598	9.482	8.752

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Ornithine decarboxylase (ODC1)	DTT	ODC1	5.20E-35	1.58	2.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5139).
2	2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.