Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVIKJZ)

Drug Name

Cinryze Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hereditary angioedema	4A00.14	Approved	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C1 esterase inhibitor (SERPING1)	TTVQ6R9	IC1_HUMAN	Modulator	[2]
Complement C1s component (C1S)	TT7LRQH	C1S_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Complement C1s component (C1S)	DTT	C1S	12.194	10.051	9.335	8.798

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Hereditary angioedema

ICD Disease Classification

4A00.14

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Complement C1s component (C1S)	DTT	C1S	5.50E-01	1.09	0.91

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.
2	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.