Details of the Drug

General Information of Drug (ID: DMVIKJZ)

Drug Name

Cinryze

Indication

Disease Entry	ICD 11	Status	REF
Hereditary angioedema	4A00.14	Approved	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C1 esterase inhibitor (SERPING1)	TTVQ6R9	IC1_HUMAN	Modulator	[2]
Complement C1s component (C1S)	TT7LRQH	C1S_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Hereditary angioedema

ICD Disease Classification

4A00.14

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Complement C1s component (C1S)	DTT	C1S	5.50E-01	1.09	0.91

Molecular Expression Atlas (MEA)

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References

1	Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.
2	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.