Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVIRN3)

Drug Name
N-DESMETHYLCLOZAPINE Drug Info
Indication
Disease Entry ICD 11 Status REF
Schizoaffective disorder 6A21 Phase 2 [1]
Schizophrenia 6A20 Phase 2 [1]
Cross-matching ID
PubChem CID
135409468
ChEBI ID
CHEBI:64050
CAS Number
CAS 6104-71-8
TTD Drug ID
DMVIRN3

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M1 (CHRM1) TTZ9SOR ACM1_HUMAN Modulator [2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Schizoaffective disorder
ICD Disease Classification 6A21
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Muscarinic acetylcholine receptor M1 (CHRM1) DTT CHRM1 4.61E-07 -0.59 -0.73
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 333).
2 N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarin... Neuropsychopharmacology. 2005 Nov;30(11):1986-95.