Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVWHTG)

Drug Name
Afamelanotide Drug Info
Synonyms [Nle4,dPhe7]alpha-MSH; alpha-NDP-MSH; NDP-MSH
Indication
Disease Entry ICD 11 Status REF
Erythropoietic porphyrias 5C58.12 Approved [1]
Erythropoietic protoporphyria 5C58.12 Approved [2]
Vitiligo ED63.0 Phase 2 [3]
Cross-matching ID
PubChem CID
16197727
CAS Number
CAS 75921-69-6
TTD Drug ID
DMVWHTG

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melanocortin receptor 1 (MC1R) TT0MV2T MSHR_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Melanocortin receptor 1 (MC1R) DTT MC1R 5.907 5.989 5.883 6.877
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Erythropoietic porphyrias
ICD Disease Classification 5C58.12
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Melanocortin receptor 1 (MC1R) DTT MC1R 1.44E-06 0.41 2.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 Afamelanotide FDA Label
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)