Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVZL26)

• Drug Name: 3,4-Dihydroxycinnamic Acid Drug Info
• Synonyms: Caffeic acid; caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 3-(3,4-dihydroxyphenyl)acrylic acid; 501-16-6; (E)-3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; trans-caffeic acid; trans-Caffeate; 3,4-Dihydroxy-trans-cinnamate; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-; Cinnamic acid, 3,4-dihydroxy-; 3-(3,4-Dihydroxyphenyl)propenoic acid; UNII-U2S3A33KVM; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene

Indication

Disease Entry	ICD 11	Status	REF
Thrombocytopenia	3B64	Phase 4	[1]

• Cross-matching ID:
  PubChem CID: 689043
  ChEBI ID: CHEBI:16433
  CAS Number: CAS 331-39-5
  TTD Drug ID: DMVZL26

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[2]
Macrophage migration inhibitory factor (MIF)	TT2AST1	MIF_HUMAN	Inhibitor	[3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Thrombocytopenia
• ICD Disease Classification: 3B64

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

References

• [1] ClinicalTrials.gov (NCT02556814) Caffeic Acid Combining High-dose Dexamethasone in Management of ITP. U.S. National Institutes of Health.
• [2] Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity. Neurosci Lett. 2008 Nov 7;445(1):1-6.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.