Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW2LD5)

• Drug Name: Nicotinyl hydroxamic acid derivative 1 Drug Info
• Synonyms: PMID26815044-Compound-120

Indication

Disease Entry	ICD 11	Status	REF
Albinism	EC23.2	Patented	[1]
Ephelides	ED61.0	Patented	[1]
Melasma	ED60.1	Patented	[1]
Menkes disease	5C64.0	Patented	[1]
Senile lentigines	ED61.0	Patented	[1]

• Cross-matching ID:
  PubChem CID: 71211
  CAS Number: CAS 5657-61-4
  TTD Drug ID: DMW2LD5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Albinism
• ICD Disease Classification: EC23.2

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

References

• [1] Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62.