Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW63TQ)

Drug Name
PF-06741086 Drug Info
Synonyms marstacimab
Indication
Disease Entry ICD 11 Status REF
Hemophilia 3B10.0 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMW63TQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tissue factor pathway inhibitor (TFPI) TT068JH TFPI1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tissue factor pathway inhibitor (TFPI) DTT TFPI 6.785 5.293 7.315 5.975
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Hemophilia
ICD Disease Classification 3B10.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tissue factor pathway inhibitor (TFPI) DTT TFPI 1.27E-08 0.14 0.84
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03938792) Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Patients With Severe Hemophilia A or B. U.S. National Institutes of Health.
2 Neutralizing Antibody Assay Development with High Drug and Target Tolerance to Support Clinical Development of an Anti-TFPI Therapeutic Monoclonal Antibody. AAPS J. 2019 Mar 29;21(3):46.