Details of the Drug

General Information of Drug (ID: DMW63TQ)

Drug Name

PF-06741086

Synonyms

marstacimab

Indication

Disease Entry	ICD 11	Status	REF
Hemophilia	3B10.0	Phase 3	[1]
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Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tissue factor pathway inhibitor (TFPI)	TT068JH	TFPI1_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Hemophilia

ICD Disease Classification

3B10.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tissue factor pathway inhibitor (TFPI)	DTT	TFPI	1.27E-08	0.14	0.84

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT03938792) Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Patients With Severe Hemophilia A or B. U.S. National Institutes of Health.
2	Neutralizing Antibody Assay Development with High Drug and Target Tolerance to Support Clinical Development of an Anti-TFPI Therapeutic Monoclonal Antibody. AAPS J. 2019 Mar 29;21(3):46.