Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW6YLS)

Drug Name

Deoxycorticosterone Drug Info

Synonyms

11-deoxycorticosterone; 21-hydroxyprogesterone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor messenger RNA (GCR mRNA)	TTOZRK6	GCR_HUMAN	Agonist	[2]
Mineralocorticoid receptor (MR)	TT26PHO	MCR_HUMAN	Agonist	[3]

------------------------------------------------------------------------------------

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Steroid 11-beta-hydroxylase (CYP11B1)	DEPE0RD	C11B1_HUMAN	Investigative	[4]
Aldosterone synthase (CYP11B2)	DE6TYUK	C11B2_HUMAN	Investigative	[5]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucocorticoid receptor messenger RNA (GCR mRNA)	DTT	NR3C1	7.153	7.278	7.017	7.331
Mineralocorticoid receptor (MR)	DTT	NR3C2	5.85	7.414	6.42	7.379
Steroid 11-beta-hydroxylase (CYP11B1)	DME	CYP11B1	5.647	4.954	5.678	6.194
Aldosterone synthase (CYP11B2)	DME	CYP11B2	2.807	2.485	2.379	2.632

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucocorticoid receptor messenger RNA (GCR mRNA)	DTT	NR3C1	3.19E-02	0.54	1.67
Mineralocorticoid receptor (MR)	DTT	NR3C2	7.31E-01	-5.31E-04	-1.53E-03
Steroid 11-beta-hydroxylase (CYP11B1)	DME	CYP11B1	2.70E-01	9.19E-02	9.75E-01
Aldosterone synthase (CYP11B2)	DME	CYP11B2	1.08E-01	-2.14E-01	-1.14E+00

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2871).
2	Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding. J Biol Chem. 2000Jun 23;275(25):19041-9.
3	Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol. 1993 Oct 15;247(2):145-54.
4	Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
5	Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1. Biochemistry. 2002 Feb 19;41(7):2311-21.