Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPE0RD)

DME Name Steroid 11-beta-hydroxylase (CYP11B1)
Synonyms Steroid 11-beta-hydroxylase CYP11B1; Cytochrome P-450c11; Mitochondrial cytochrome P450 11B1; Cytochrome P450C11; CYP11B1; CYPXIB1; S11BH
Gene Name CYP11B1
UniProt ID
C11B1_HUMAN
INTEDE ID
DME0027
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
1584
EC Number EC: 1.14.15.4
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.4
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
Function
This enzyme is involved in the biosynthesis of adrenal corticoids. It catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively.
KEGG Pathway
Cortisol synthesis and secretion (hsa04927 )
Cushing syndrome (hsa04934 )
Metabolic pathways (hsa01100 )
Steroid hormone biosynthesis (hsa00140 )
Reactome Pathway
Endogenous sterols (R-HSA-211976 )
Glucocorticoid biosynthesis (R-HSA-194002 )
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) (R-HSA-5579017 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [18]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [19]
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
deoxycorticosterone DMW6YLS Discovery agent N.A. Investigative [20]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.40E-05 5.58E-02 4.46E-01
Alopecia ED70 Skin from scalp 2.16E-01 1.74E-02 1.19E-01
Alzheimer's disease 8A20 Entorhinal cortex 9.12E-01 -8.48E-04 -7.66E-03
Ankylosing spondylitis FA92.0 Pheripheral blood 6.78E-01 3.63E-02 6.33E-01
Aortic stenosis BB70 Calcified aortic valve 6.80E-01 9.28E-02 3.40E-01
Apnea 7A40 Hyperplastic tonsil 6.45E-01 2.06E-03 1.35E-02
Arthropathy FA00-FA5Z Peripheral blood 3.15E-01 6.02E-02 6.30E-01
Asthma CA23 Nasal and bronchial airway 3.74E-02 -5.60E-02 -2.08E-01
Atopic dermatitis EA80 Skin 8.06E-07 1.01E-01 1.25E+00
Autism 6A02 Whole blood 2.07E-01 -2.33E-03 -1.53E-02
Autoimmune uveitis 9A96 Peripheral monocyte 9.60E-03 -1.90E-01 -2.37E+00
Autosomal dominant monocytopenia 4B04 Whole blood 4.59E-01 -6.23E-02 -4.51E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.25E-01 3.88E-02 2.39E-01
Batten disease 5C56.1 Whole blood 3.90E-01 1.40E-02 1.60E-01
Behcet's disease 4A62 Peripheral blood 2.69E-01 5.23E-02 6.33E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.76E-01 -2.95E-02 -2.59E-01
Bladder cancer 2C94 Bladder tissue 1.19E-08 4.43E-01 4.33E+00
Breast cancer 2C60-2C6Z Breast tissue 4.31E-04 -2.65E-02 -1.28E-01
Cardioembolic stroke 8B11.20 Whole blood 1.63E-02 6.61E-02 5.06E-01
Cervical cancer 2C77 Cervical tissue 5.07E-01 -2.42E-02 -1.17E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.56E-01 -2.62E-02 -1.46E-01
Chronic hepatitis C 1E51.1 Whole blood 7.02E-01 1.13E-02 6.56E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 4.55E-02 7.20E-02 5.54E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 7.89E-01 -3.53E-03 -2.90E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.90E-01 4.99E-02 4.99E-01
Colon cancer 2B90 Colon tissue 5.95E-01 8.29E-03 5.20E-02
Coronary artery disease BA80-BA8Z Peripheral blood 2.16E-01 -6.62E-02 -6.01E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.59E-01 2.39E-02 2.58E-01
Endometriosis GA10 Endometrium tissue 7.83E-01 1.92E-02 1.40E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 6.28E-01 7.50E-03 7.49E-02
Familial hypercholesterolemia 5C80.00 Whole blood 6.10E-01 -2.97E-02 -2.14E-01
Gastric cancer 2B72 Gastric tissue 7.49E-01 4.50E-02 2.56E-01
Glioblastopma 2A00.00 Nervous tissue 1.33E-05 7.19E-02 3.96E-01
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 5.04E-01 -7.49E-02 -6.91E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.25E-07 -6.04E-01 -3.90E+00
Head and neck cancer 2D42 Head and neck tissue 1.86E-02 5.56E-02 4.01E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.11E-01 -9.34E-02 -5.99E-01
Huntington's disease 8A01.10 Whole blood 3.96E-01 3.95E-02 2.98E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 2.76E-01 -7.27E-02 -4.21E-01
Immunodeficiency 4A00-4A20 Peripheral blood 8.46E-01 1.94E-02 2.01E-01
Influenza 1E30 Whole blood 1.46E-01 1.02E-01 1.13E+00
Interstitial cystitis GC00.3 Bladder tissue 1.37E-01 6.61E-02 1.07E+00
Intracranial aneurysm 8B01.0 Intracranial artery 6.51E-01 -8.58E-03 -5.01E-02
Irritable bowel syndrome DD91.0 Rectal colon tissue 2.62E-01 6.73E-02 3.22E-01
Ischemic stroke 8B11 Peripheral blood 6.80E-02 1.15E-01 1.33E+00
Juvenile idiopathic arthritis FA24 Peripheral blood 4.91E-04 7.60E-02 4.10E-01
Lateral sclerosis 8B60.4 Skin 9.15E-01 3.38E-02 2.23E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 7.95E-01 4.03E-02 2.04E-01
Liver cancer 2C12.0 Liver tissue 1.31E-01 -5.48E-02 -3.41E-01
Liver failure DB99.7-DB99.8 Liver tissue 6.40E-02 6.03E-02 4.57E-01
Lung cancer 2C25 Lung tissue 2.69E-08 5.74E-02 4.68E-01
Lupus erythematosus 4A40 Whole blood 1.45E-03 -1.30E-01 -4.76E-01
Major depressive disorder 6A70-6A7Z Hippocampus 5.19E-01 5.57E-03 4.94E-02
Major depressive disorder 6A70-6A7Z Whole blood 6.49E-01 -7.39E-03 -4.07E-02
Melanoma 2C30 Skin 6.02E-01 5.74E-02 1.73E-01
Multiple myeloma 2A83.1 Peripheral blood 3.10E-01 -1.23E-02 -1.01E-01
Multiple myeloma 2A83.1 Bone marrow 2.24E-06 -2.40E-01 -4.68E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.42E-01 2.46E-02 1.12E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.22E-01 -2.28E-02 -2.28E-01
Myelofibrosis 2A20.2 Whole blood 4.97E-03 8.04E-02 7.89E-01
Myocardial infarction BA41-BA50 Peripheral blood 5.21E-02 1.91E-01 5.55E-01
Myopathy 8C70.6 Muscle tissue 1.26E-01 -1.40E-01 -6.84E-01
Neonatal sepsis KA60 Whole blood 9.09E-04 -5.45E-02 -3.62E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.25E-02 -3.81E-01 -1.19E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 3.05E-01 -4.09E-02 -6.74E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 3.33E-01 4.19E-03 8.52E-02
Olive pollen allergy CA08.00 Peripheral blood 5.22E-02 3.55E-02 6.73E-01
Oral cancer 2B6E Oral tissue 3.02E-04 -1.65E-01 -9.32E-01
Osteoarthritis FA00-FA0Z Synovial tissue 9.12E-01 -4.23E-02 -2.15E-01
Osteoporosis FB83.1 Bone marrow 3.62E-01 4.55E-02 1.26E+00
Ovarian cancer 2C73 Ovarian tissue 1.27E-01 -1.05E-01 -2.11E-01
Pancreatic cancer 2C10 Pancreas 2.04E-02 -1.26E-01 -7.75E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 5.01E-01 9.11E-03 1.80E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.97E-02 -8.33E-02 -1.16E+00
Pituitary cancer 2D12 Pituitary tissue 7.30E-01 1.32E-01 1.76E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.25E-01 8.15E-02 8.48E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 4.23E-01 1.69E-03 2.29E-02
Polycythemia vera 2A20.4 Whole blood 6.92E-05 8.36E-02 7.43E-01
Pompe disease 5C51.3 Biceps muscle 1.47E-01 -3.48E-02 -2.74E-01
Preterm birth KA21.4Z Myometrium 7.35E-01 8.18E-02 1.47E+00
Prostate cancer 2C82 Prostate 2.68E-02 -3.49E-01 -7.73E-01
Psoriasis EA90 Skin 2.86E-03 -5.13E-02 -3.02E-01
Rectal cancer 2B92 Rectal colon tissue 9.21E-02 -1.66E-01 -1.00E+00
Renal cancer 2C90-2C91 Kidney 2.14E-01 -3.63E-02 -2.22E-01
Retinoblastoma 2D02.2 Uvea 1.55E-06 -2.52E-01 -3.89E+00
Rheumatoid arthritis FA20 Synovial tissue 6.11E-01 -1.05E-03 -4.33E-03
Rhinovirus infection CA42.1 Nasal epithelium tissue 7.38E-01 2.47E-02 2.61E-01
Schizophrenia 6A20 Prefrontal cortex 1.41E-01 2.95E-02 1.67E-01
Schizophrenia 6A20 Superior temporal cortex 1.35E-01 -7.29E-02 -9.24E-01
Scleroderma 4A42.Z Whole blood 3.62E-01 9.37E-03 1.14E-01
Seizure 8A60-8A6Z Whole blood 3.60E-01 -2.21E-02 -1.67E-01
Sensitive skin EK0Z Skin 2.20E-01 -9.58E-02 -1.23E+00
Sepsis with septic shock 1G41 Whole blood 7.96E-03 7.35E-02 4.23E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.64E-01 3.15E-01 1.03E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 4.66E-01 7.70E-02 6.58E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.87E-01 1.07E-01 1.40E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.36E-01 -1.80E-01 -8.77E-01
Skin cancer 2C30-2C3Z Skin 2.83E-01 1.95E-02 8.03E-02
Thrombocythemia 3B63 Whole blood 3.76E-02 2.38E-02 2.54E-01
Thrombocytopenia 3B64 Whole blood 1.89E-01 1.15E-01 1.02E+00
Thyroid cancer 2D10 Thyroid 2.06E-03 4.64E-02 2.93E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.81E-01 -8.16E-02 -4.60E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 9.39E-02 1.86E-01 1.77E+00
Type 2 diabetes 5A11 Liver tissue 2.70E-01 9.19E-02 9.75E-01
Ureter cancer 2C92 Urothelium 7.30E-01 -1.55E-02 -1.07E-01
Uterine cancer 2C78 Endometrium tissue 4.27E-08 -1.03E-01 -5.72E-01
Vitiligo ED63.0 Skin 5.48E-01 -3.51E-02 -3.11E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name Steroid 11-beta-hydroxylase (CYP11B1) DTT Info
DME DTT Type Successful
3 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [1]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [2]
Osilodrostat DMIJC9X Cushing disease 5A70 Approved [3]
148 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(3-((1H-imidazol-1-yl)methyl)phenyl)methanol DMBZJT5 Discovery agent N.A. Investigative [1]
(4-((1H-imidazol-1-yl)methyl)phenyl)methanol DMWS35F Discovery agent N.A. Investigative [1]
1-(2-Phenoxy-ethyl)-1H-imidazole DMOMAXJ Discovery agent N.A. Investigative [4]
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole DMP93HZ Discovery agent N.A. Investigative [5]
1-(3-Bromobenzyl)-1H-imidazole DMA59TP Discovery agent N.A. Investigative [1]
1-(3-Chlorobenzyl)-1H-imidazole DM3SQBH Discovery agent N.A. Investigative [1]
1-(3-Fluorobenzyl)-1H-imidazole DM18DB3 Discovery agent N.A. Investigative [1]
1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole DM16U5F Discovery agent N.A. Investigative [6]
1-(4-Aminobenzyl)-1H-imidazole DMOZAM6 Discovery agent N.A. Investigative [1]
1-(4-Bromobenzyl)-1H-imidazole DM2C7U0 Discovery agent N.A. Investigative [1]
1-(4-Bromobenzyl)-5-phenyl-1H-imidazole DMCW8RT Discovery agent N.A. Investigative [1]
1-(4-Chlorobenzyl)-5-phenyl-1H-imidazole DMASLUF Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-(2-fluorophenyl)-1H-imidazole DMKDAJ2 Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole DMAJXYO Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-(3-fluorophenyl)-1H-imidazole DMVS4D5 Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-(3-methylphenyl)-1H-imidazole DMI8UC7 Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-(4-fluorophenyl)-1H-imidazole DM7C3VD Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-(4-methylphenyl)-1H-imidazole DMQX37R Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-(4-pyridyl)-1H-imidazole DM372EG Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-bromo-1H-imidazole DMBUMDG Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-formyl-1H-imidazole DM2THVK Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole DMCUE25 Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-methyl-1H-imidazole DMKC52N Discovery agent N.A. Investigative [1]
1-(4-Cyanobenzyl)-5-phenyl-1H-imidazole DMQF8DY Discovery agent N.A. Investigative [1]
1-(4-fluorobenzyl)-1H-imidazole DMBJCGA Discovery agent N.A. Investigative [1]
1-(4-Fluorobenzyl)-5-phenyl-1H-imidazole DMT2ZSV Discovery agent N.A. Investigative [1]
1-(4-Methoxybenzyl)-5-phenyl-1H-imidazole DMSWJKZ Discovery agent N.A. Investigative [1]
1-(6-Methoxy-naphthalen-2-yl)-1H-imidazole DMEHK4F Discovery agent N.A. Investigative [6]
1-Benzyl-5-phenyl-1H-imidazole DM8GUN9 Discovery agent N.A. Investigative [1]
1-Ethyl-3-imidazol-1-ylmethyl-1H-indole DM5UWH9 Discovery agent N.A. Investigative [7]
1-Naphthalen-2-yl-1H-imidazole DMTBZJL Discovery agent N.A. Investigative [6]
1-Phenyl-2-pyridin-3-yl-propan-1-one DM8EDI7 Discovery agent N.A. Investigative [8]
2-Methyl-1,2-di-pyridin-3-yl-1-methoxypropane DMIWX21 Discovery agent N.A. Investigative [8]
2-Methyl-1,2-di-pyridin-3-yl-propan-1-one oxime DMB0NEL Discovery agent N.A. Investigative [8]
2-Methyl-1,2-di-pyridin-3-yl-propane DMC3ET2 Discovery agent N.A. Investigative [8]
2-Methyl-1,2-di-pyridin-3-yl-propylchloride DMQHM7R Discovery agent N.A. Investigative [8]
2-Methyl-1,2-di-pyridin-3-yl-propyliodide DM561MH Discovery agent N.A. Investigative [8]
2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-ol DMLX9RG Discovery agent N.A. Investigative [8]
2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-one DMZY72I Discovery agent N.A. Investigative [8]
3-((1H-imidazol-1-yl)methyl)aniline DMZ9L6Q Discovery agent N.A. Investigative [1]
3-(1,1-Dimethyl-2-phenyl-ethyl)-pyridine DM57ZMJ Discovery agent N.A. Investigative [8]
3-(1,2-dihydroacenaphthylen-3-yl)pyridine DMXZBQL Discovery agent N.A. Investigative [9]
3-(1,2-dihydroacenaphthylen-5-yl)pyridine DMHB4PA Discovery agent N.A. Investigative [9]
3-(1-Benzyl-1H-imidazol-5-yl)-1-propanol DMGYDEK Discovery agent N.A. Investigative [1]
3-(1-Chloro-7-methoxy-naphthalen-2-yl)-pyridine DMLH7YI Discovery agent N.A. Investigative [6]
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine DMR7M82 Discovery agent N.A. Investigative [5]
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine DMU5HMC Discovery agent N.A. Investigative [5]
3-(1H-inden-2-yl)pyridine DM9ZDIK Discovery agent N.A. Investigative [5]
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridine DMTS4YD Discovery agent N.A. Investigative [10]
3-(2-Chloro-1,1-dimethyl-2-phenyl-ethyl)-pyridine DMDS4Q0 Discovery agent N.A. Investigative [8]
3-(3,4-dihydronaphthalen-2-yl)pyridine DM0VL17 Discovery agent N.A. Investigative [5]
3-(3-Benzyl-6-methoxynaphthalen-2-yl)pyridine DM1325C Discovery agent N.A. Investigative [11]
3-(3-Benzylnaphthalen-2-yl)pyridine DM9S36A Discovery agent N.A. Investigative [11]
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine DM2YLBD Discovery agent N.A. Investigative [5]
3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine DMM7BQP Discovery agent N.A. Investigative [5]
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine DMDR20P Discovery agent N.A. Investigative [5]
3-(5,6,7,8-Tetrahydronaphthalen-2-yl)pyridine DMTVYLM Discovery agent N.A. Investigative [10]
3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine DMUIXNS Discovery agent N.A. Investigative [6]
3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine DM67DVU Discovery agent N.A. Investigative [6]
3-(5-methoxy-1H-inden-2-yl)pyridine DMTJXOU Discovery agent N.A. Investigative [5]
3-(6-Bromo-naphthalen-2-yl)-pyridine DM63BI9 Discovery agent N.A. Investigative [6]
3-(6-Ethoxy-naphthalen-2-yl)-pyridine DMUQ0WI Discovery agent N.A. Investigative [6]
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine DMAJHXO Discovery agent N.A. Investigative [12]
3-(6-Methoxy-3-methylnaphthalen-2-yl)pyridine DMISLV4 Discovery agent N.A. Investigative [12]
3-(6-Methoxynaphthalen-2-yl)-4-methylpyridine DM0GXFB Discovery agent N.A. Investigative [12]
3-(6-Methoxynaphthalen-2-yl)-5-phenylpyridine DM704R5 Discovery agent N.A. Investigative [12]
3-(6-Methoxynaphthalen-2-yl)pyridin-4-amine DMN75RD Discovery agent N.A. Investigative [12]
3-(6-methoxynaphthalen-2-yl)pyridine DMYRJAB Discovery agent N.A. Investigative [11]
3-(naphthalen-2-yl)pyridine DMJRBT1 Discovery agent N.A. Investigative [11]
3-Ethoxy-5-(6-methoxynaphthalen-2-yl)pyridine DMWZDA1 Discovery agent N.A. Investigative [12]
3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol DMJ3WNP Discovery agent N.A. Investigative [13]
3-Imidazol-1-yl-quinoline DMVF6OQ Discovery agent N.A. Investigative [6]
3-Imidazol-1-ylmethyl-1H-indole DMBZ60O Discovery agent N.A. Investigative [7]
3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole DMAQOL0 Discovery agent N.A. Investigative [7]
3-Indan-(1E)-ylidenemethyl-pyridine DMYH6A2 Discovery agent N.A. Investigative [14]
3-Indan-(1Z)-ylidenemethyl-pyridine DMTQERW Discovery agent N.A. Investigative [14]
3-MeSO2-DDE DMAWEQH Discovery agent N.A. Investigative [2]
3-methoxy-5-(6-methoxynaphthalen-2-yl)pyridine DMF2IW8 Discovery agent N.A. Investigative [12]
3-Phenanthren-9-yl-pyridine DM7RWQT Discovery agent N.A. Investigative [6]
3-[(Z)-2-phenylvinyl]pyridine DMNPKZ6 Discovery agent N.A. Investigative [5]
3-[1-(4-Bromobenzyl)-1H-imidazol-5-yl]-1-propanol DM7URMW Discovery agent N.A. Investigative [1]
3-[1-(4-Cyanobenzyl)-1H-imidazol-5-yl]-1-propanol DM63IKF Discovery agent N.A. Investigative [1]
3-[3-(4-Methoxybenzyl)naphthalen-2-yl]pyridine DM8NRJQ Discovery agent N.A. Investigative [11]
3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM0XD6T Discovery agent N.A. Investigative [14]
3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMMDIB9 Discovery agent N.A. Investigative [14]
3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMZS20Y Discovery agent N.A. Investigative [14]
3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMJN93U Discovery agent N.A. Investigative [14]
3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine DMUEVAQ Discovery agent N.A. Investigative [14]
3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMCXSIH Discovery agent N.A. Investigative [14]
3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM8TWLO Discovery agent N.A. Investigative [14]
3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMN60YG Discovery agent N.A. Investigative [14]
3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine DMLJQZS Discovery agent N.A. Investigative [14]
3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine DMMTUON Discovery agent N.A. Investigative [14]
3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMWSFIR Discovery agent N.A. Investigative [14]
3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMN42I5 Discovery agent N.A. Investigative [14]
3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM9AW5U Discovery agent N.A. Investigative [14]
3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMB3XYE Discovery agent N.A. Investigative [14]
3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DMVWIQ2 Discovery agent N.A. Investigative [14]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diamine DMZ0H5X Discovery agent N.A. Investigative [13]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol DM6Z5EK Discovery agent N.A. Investigative [13]
4'-(Pyridin-4-ylmethyl)biphenyl-3-amine DMR8O1B Discovery agent N.A. Investigative [13]
4'-(Pyridin-4-ylmethyl)biphenyl-4-amine DM8HXYS Discovery agent N.A. Investigative [13]
4-((1H-imidazol-1-yl)methyl)benzonitrile DMFUBRC Discovery agent N.A. Investigative [1]
4-((3',4'-Difluorobiphenyl-4-yl)methyl)pyridine DMHN5OL Discovery agent N.A. Investigative [13]
4-(2-Imidazol-1-yl-ethoxy)-benzamide DMB6SNE Discovery agent N.A. Investigative [4]
4-(4'-Fluoro-biphenyl-4-ylmethyl)pyridine DM52NMU Discovery agent N.A. Investigative [13]
4-(4-(thiophen-2-yl)benzyl)pyridine DMVXJU6 Discovery agent N.A. Investigative [13]
4-(4-(thiophen-3-yl)benzyl)pyridine DM7I21V Discovery agent N.A. Investigative [13]
4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine DM3ACVD Discovery agent N.A. Investigative [5]
4-(6-Methoxy-3-methylnaphthalen-2-yl)isoquinoline DMRPU0V Discovery agent N.A. Investigative [12]
4-(6-Methoxynaphthalen-2-yl)isoquinoline DM51XDA Discovery agent N.A. Investigative [12]
4-Indan-(1Z)-ylidenemethyl-pyridine DM25DR7 Discovery agent N.A. Investigative [14]
4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine DM04MK7 Discovery agent N.A. Investigative [13]
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine DMIEMWA Discovery agent N.A. Investigative [13]
4-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine DMI7YAQ Discovery agent N.A. Investigative [14]
4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMQKHXN Discovery agent N.A. Investigative [14]
4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DMZL8KN Discovery agent N.A. Investigative [14]
4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DM1Z3DG Discovery agent N.A. Investigative [14]
4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMY08FE Discovery agent N.A. Investigative [14]
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMHDZUO Discovery agent N.A. Investigative [14]
5-(6-Methoxynaphthalen-2-yl)pyridin-3-ol DMMPAWD Discovery agent N.A. Investigative [12]
5-Indan-(1E)-ylidenemethyl-1H-imidazole DMW8AOM Discovery agent N.A. Investigative [15]
5-Indan-(1Z)-ylidenemethyl-1H-imidazole DMKLY20 Discovery agent N.A. Investigative [15]
5-Naphthalen-2-yl-1H-imidazole DMK0PAL Discovery agent N.A. Investigative [6]
5-Naphthalen-2-yl-oxazole DMTH3BW Discovery agent N.A. Investigative [6]
5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one DMLRM9Z Discovery agent N.A. Investigative [10]
5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one DMQYIBC Discovery agent N.A. Investigative [10]
5-[4-(Pyridin-4-ylmethyl)phenyl]-1H-indole DMW8RLN Discovery agent N.A. Investigative [13]
5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole DMV7QU3 Discovery agent N.A. Investigative [15]
5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole DMZICL8 Discovery agent N.A. Investigative [15]
5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine DM2RIHT Discovery agent N.A. Investigative [14]
6-(4-Methylpyridin-3-yl)-2-naphthonitrile DMTV753 Discovery agent N.A. Investigative [12]
6-(pyridin-3-yl)-2-naphthonitrile DMC3SJI Discovery agent N.A. Investigative [12]
6-Isoquinolin-4-yl-3,4-dihydroquinolin-2(1H)-one DM2WUZP Discovery agent N.A. Investigative [10]
6-Pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-2-ol DM86XG5 Discovery agent N.A. Investigative [10]
6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one DMG5ABT Discovery agent N.A. Investigative [10]
6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one DMIM5DL Discovery agent N.A. Investigative [10]
6-Pyridin-3-yl-3,4-dihydroquinoline-2(1H)-thione DMHAS2B Discovery agent N.A. Investigative [10]
6-Pyridin-3-yl-naphthalen-2-ol DMGWNDB Discovery agent N.A. Investigative [6]
6-[4-(Pyridin-4-ylmethyl)phenyl]naphthalen-2-ol DM40LQ9 Discovery agent N.A. Investigative [13]
7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol DMRPFNU Discovery agent N.A. Investigative [16]
7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one DMW8XME Discovery agent N.A. Investigative [10]
BENZYLIMIDAZOLE DMNRHSO Discovery agent N.A. Investigative [1]
Methyl 3-(1-Benzyl-1H-imidazol-5-yl)-propanoate DMWM814 Discovery agent N.A. Investigative [1]
METYRAPOL DMHTGCR Discovery agent N.A. Investigative [8]
N-(4'-Isonicotinoylbiphenyl-3-yl)acetamide DM2N3TG Discovery agent N.A. Investigative [13]
R-fadrozole DMJG4U0 Discovery agent N.A. Investigative [1]
SL125 DMEIZ20 Congestive heart failure BD10 Investigative [17]
⏷ Show the Full List of 148 Investigative Drug(s)

References

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