Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW8ORN)

Drug Name
DR-4004 Drug Info
Synonyms compound 7 [PMID 10052959]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9843179
CAS Number
CAS 201608-41-5
TTD Drug ID
DMW8ORN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 7 receptor (HTR7) TTO9X1H 5HT7R_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 7 receptor (HTR7) DTT HTR7 1.561 1.233 0.848 1.485
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 7 receptor (HTR7) DTT HTR7 9.79E-01 -0.08 -0.32
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Tetrahydrobenzindoles: selective antagonists of the 5-HT7 receptor. J Med Chem. 1999 Feb 25;42(4):533-5.
2 Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812.