Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWDEN0)

Drug Name
Amylin Drug Info
Synonyms
Amlintide; Pancreatic amylin; IAPP; Islet amyloid polypeptide; Insulinoma amyloid peptide; Diabetes-associated peptide; Insulinoma amyloid polypeptide; Amylin (human); Amlintide [USAN:INN]; 122384-88-7; Human islet amyloid peptide; AC001; AC 001; SCHEMBL374892; C8H16N2O4.C4H10; LS-172011; FT-0688968
Cross-matching ID
PubChem CID
16132430
CAS Number
CAS 106602-62-4
TTD Drug ID
DMWDEN0
INTEDE Drug ID
DR1920

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melanocortin receptor 4 (MC4R) TTD0CIQ MC4R_HUMAN Agonist [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Matrix metalloproteinase-2 (MMP-2) DE0LW4X MMP2_HUMAN Phase 4 [2]
Matrix metalloproteinase-9 (MMP-9) DEA0BDX MMP9_HUMAN Phase 4 [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Melanocortin receptor 4 (MC4R) DTT MC4R 5.904 5.009 4.548 4.597
Matrix metalloproteinase-9 (MMP-9) DME MMP9 6.725 7.358 6.384 6.921
Matrix metalloproteinase-2 (MMP-2) DME MMP2 5.766 9.299 8.247 8.608
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Melanocortin receptor 4 (MC4R) DTT MC4R 5.64E-01 -0.04 -0.18
Matrix metalloproteinase-9 (MMP-9) DME MMP9 8.81E-01 4.58E-02 1.18E-01
Matrix metalloproteinase-2 (MMP-2) DME MMP2 2.60E-01 6.54E-02 3.83E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Novel anti-obesity drugs. Expert Opin Investig Drugs. 2000 Jun;9(6):1317-26.
2 Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide. J Biol Chem. 2013 Feb 1;288(5):3553-9.