Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWDENZ)

Drug Name
2-amino-2-(2,3-difluorophenyl)acetic acid Drug Info
Synonyms
2-amino-2-(2,3-difluorophenyl)acetic Acid; 237424-16-7; 2,3-Difluoro-DL-phenylglycine; 2,3-DIFLUOR-DL-PHENYLGLYCINE; CHEMBL204804; AC1MC6PF; MolPort-000-165-847; JRD-0494; SBB090537; BDBM50179717; amino(2,3-difluorophenyl)acetic acid; AKOS012977999; AB26703; PS-11465; alpha-Amino-2,3-difluoro-benzeneacetic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2737049
TTD Drug ID
DMWDENZ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.