Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWE6V1)

Drug Name

Putrescine Drug Info

Synonyms

putrescine; 1,4-diaminobutane; 1,4-butanediamine; butane-1,4-diamine; 110-60-1; tetramethylenediamine; Butylenediamine; Putrescin; 1,4-Butylenediamine; Tetramethyldiamine; 1,4-Tetramethylenediamine; putrescina; Putreszin; Tetramethylendiamin; UNII-V10TVZ52E4; NSC 60545; BRN 0605282; H2N(CH2)4NH2; CCRIS 6751; AI3-25444; 1,4-Diamino-n-butane; EINECS 203-782-3; 1,4-Diaminobutane, 99%; CHEMBL46257; V10TVZ52E4; CHEBI:17148; KIDHWZJUCRJVML-UHFFFAOYSA-N; MFCD00008235; 1,4-butanediammonium; Diaminobutane dihydrochloride; PUT; HSDB 7865

Indication

Disease Entry	ICD 11	Status	REF
Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 1045
ChEBI ID: CHEBI:17148
CAS Number: CAS 110-60-1
TTD Drug ID: DMWE6V1
INTEDE Drug ID: DR1790

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[2]
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Amiloride-sensitive amine oxidase (AOC1)	DETECWH	AOC1_HUMAN	Discontinued	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Ornithine decarboxylase (ODC1)	DTT	ODC1	9.956	8.598	9.482	8.752
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	6.747	6.763	7.033	6.593
Amiloride-sensitive amine oxidase (AOC1)	DME	AOC1	5.536	10.003	9.42	10.759

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Burn and burn infection

ICD Disease Classification

ND90-NE2Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Ornithine decarboxylase (ODC1)	DTT	ODC1	5.20E-35	1.58	2.43
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	4.41E-05	0.37	0.61
Amiloride-sensitive amine oxidase (AOC1)	DME	AOC1	1.79E-14	6.00E-01	1.28E+00

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2388).
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	Putrescine metabolism and the study of diamine oxidase activity in vivo. Agents Actions. 1981 Apr;11(1-2):20-7.